Ashwagandha
Evidence review
How Much Does Ashwagandha Reduce Stress?
Ashwagandha at a dosage of 300 mg daily has been shown to reduce cortisol levels by approximately 28% in chronically stressed adults. (PMID: 38003702)
How Does Ashwagandha Work in the Body?
Ashwagandha primarily acts as an adaptogen, modulating the hypothalamic-pituitary-adrenal (HPA) axis and reducing cortisol production in response to stress.
What is the Recommended Ashwagandha Dosage Protocol?
| Phase | Dosage | Duration | Clinical Notes |
|---|---|---|---|
| Standard | 300 mg | Ongoing | Best taken with food for improved absorption. |
Clinical Contraindications and Liver Enzyme Interactions
Evidence-Based Product Evaluation: Which Ashwagandha to Buy?
Extraction Source / Form: KSM-66 ashwagandha extract.
Formulation for Absorption: Lipid co-factor for enhanced bioavailability.
Purity Verification: Look for a Certificate of Analysis (CoA) indicating high withanolide content and absence of heavy metals.
Based on these clinical parameters, a high-quality ashwagandha supplement should provide 300 mg of KSM-66 extract, verified by independent third-party testing.
FAQ
Q: Does ashwagandha cause drowsiness?
A: Ashwagandha may cause mild sedation in some individuals, particularly at higher doses, but it is generally well-tolerated.
Q: How long does ashwagandha take to work?
A: Users may begin to notice effects on stress and anxiety levels within 4 to 8 weeks of consistent use.
Q: Can ashwagandha be taken with antidepressants?
A: Data on interactions with antidepressants is insufficient, so it is advisable to consult a healthcare provider before combining them.
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